1-Methylpiperazine → HCID 178434648, compound

HRID 57248Notes

Reaction equation

HRID 57248 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(N(CC)CC)C>[CH3:7][C:4]1[C:3]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([S:17]([N:25]4[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]4)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[C:2]([NH2:1])[NH:6][N:5]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178434647HCID 178434647, compound

Product 1

HCID 178434648HCID 178434648, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

the title compound (30 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (128 mg, 0.39 mmol), 4-methylpiperazine (39 mg, 0.43 mmol) and triethylamine (0.1 mL). MS (m/z, ES+): 393.1 (M+1,100%). Yield=20%.

Sources & evidence

ORD record
ord-1658c9a3d88744aa8933145669fc456e
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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