反应详情

温度

180 °C

A mixture of compound 1 (10.0 g, 50.0 mmol), CuCN (9.0 g, 100 mmol) and NMP (60 mL) was heated at 180° C. for 6 h. The mixture was cooled to room temperature, diluted with EA, then washed with H2O, brine, dried and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc=10/1) to give the desired product (3.30 g, 22.8 mmol, 45.6%) as a yellow solid.

1. temperatureThe mixture was cooled to room temperature
2. washwashed with H2O, brine
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel chromatography (petroleum ether/EtOAc=10/1)