反应详情

To a stirred solution of 4-bromophenol (200 mg) in DMF (3 mL) was added NaH (60% in oil, 46.2 mg) at room temperature. The mixture was stirred for 30 min, and 2-chloropyridine (131 mg) was added. The mixture was exposed to microwave irradiation at 230° C. for 1 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane). The product was crystallized from AcOEt/hexane to give the title compound (76 mg).

1. customirradiation at 230° C. for 1 h
2. extractionextracted with AcOEt
3. dry with materialThe organic layer was dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)
6. customThe product was crystallized from AcOEt/hexane