Hydrochloric Acid → HCID 66807131, compound

HRID 574154Notes

Reaction equation

HRID 574154 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:11]([CH2:12][CH2:13][O:14][CH3:15])[C:10](=[O:16])[N:9]([CH2:17][C:18]([NH:20][CH:21]([C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[CH:34]=3)[C:22]([NH:24][C:25]3([C:28]([O:30]CC)=[O:29])[CH2:27][CH2:26]3)=[O:23])=[O:19])[N:8]=2)=[CH:4][CH:3]=1.[OH-].[Li+].Cl>CO.O>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:11]([CH2:12][CH2:13][O:14][CH3:15])[C:10](=[O:16])[N:9]([CH2:17][C:18]([NH:20][CH:21]([C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:41])([F:40])[F:42])[CH:34]=3)[C:22]([NH:24][C:25]3([C:28]([OH:30])=[O:29])[CH2:26][CH2:27]3)=[O:23])=[O:19])[N:8]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68042620HCID 68042620, compound

Product 1

HCID 66807131HCID 66807131, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

43 mg (68 μmol) of the compound of Example 7 were dissolved in 3 ml of methanol, and 273 μl of a 1M aqueous lithium hydroxide solution (0.27 mmol) were added. The mixture was stirred at RT overnight and then acidified by addition of 1N hydrochloric acid and diluted with water. The precipitated solid was filtered off with suction, washed with a little water and dried in a vacuum drying cabinet at 50° C. This gave 32 mg (74% of theory) of the title compound.

Workup

  1. filtrationThe precipitated solid was filtered off with suction
  2. washwashed with a little water
  3. customdried in a vacuum
  4. customdrying cabinet at 50° C

Sources & evidence

ORD record
ord-29338771737c4c98806c124a858d3493
Source dataset
uspto-grants-2015_05
Patent number
US09034855B2

Reaction notes

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