反应详情

温度

80 °C

A mixture of 9-Bromo-4,4-difluoro-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl ester as a yellow solid (166.5 mg, 0.443 mmol), 2-methyl-3-butyn-2-ol (298 mg, 3.544 mmol), Pd(OAc)2 (10 mg, 0.0443 mmol), CuI (17 mg, 0.0886 mmol) and PPh3 (35 mg, 0.1329 mmol) in Et3N (20 mL) was degassed with N2, and the mixture was stirred at 80° C. overnight. The reaction mixture was cooled to room temperature, concentrated and purified by flash column chromatography (silica gel, EtOAc in hexane from 0 to 40%) to give 4,4-Difluoro-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl ester as a yellow solid (86 mg, 51%). LC-MS (ESI & APCI): 380.4 (M+1).

1. customwas degassed with N2
2. temperatureThe reaction mixture was cooled to room temperature
3. concentrationconcentrated
4. custompurified by flash column chromatography (silica gel, EtOAc in hexane from 0 to 40%)