反应详情

A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (200 mg, 1.03 mmol), 1-bromo-2-methoxyethane (280 mg, 2.01 mmol), and NaH (200 mg, 4 mmol) in THF (15 mL) was stirred at reflux for 24 hours, cooled to the ambient temperature, and concentrated in vacuo. The residue was treated with HCl(aq) and extracted with EtOAc. The insoluble solid was removed by filtration, and the organic solution was concentrated to give the title compound. MS (m/z): 253 (M+H)+.

1. temperatureat reflux for 24 hours
2. concentrationconcentrated in vacuo
3. additionThe residue was treated with HCl(aq)
4. extractionextracted with EtOAc
5. customThe insoluble solid was removed by filtration
6. concentrationthe organic solution was concentrated