反应详情

温度

140 °C

To a solution of 1-chloro-2-methylpropan-2-ol (434.4 mg, 4 mmol) in DMF (10 mL) was added K2CO3 (552 mg, 4 mmol) and 4-bromophenol (346 mg, 2 mmol), the reaction was stirred at 140° C. for 48 hours. About of 10% 4-bromophenol was remained and the reaction was poured into 30 mL of water, extracted with EA (20 mL×3), washed with 30 mL of water and brine, concentrated and purified on TLC (EA:PE=1:3) to give yellow solid. MS (m/z): 196 (M−50)+

1. extractionextracted with EA (20 mL×3)
2. washwashed with 30 mL of water and brine
3. concentrationconcentrated
4. custompurified on TLC (EA:PE=1:3)
5. customto give yellow solid