反应详情

4-bromo-N-methylaniline (700 mg, 3.76 mmol) was dissolved in DMF (20 mL), K2CO3 (1.56 g, 11.29 mmol) and 2-bromoethanol (1.41 g, 11.29 mmol) were added in. The mixture was reacted at 100° C. for 2 days. Then it was extracted by EA and brine, washed by brine, dried over Na2SO4, concentrated and purified by flash chromatography, (PE: EA=10:1 to 3:1) to give 164 mg brown oil.

1. customThe mixture was reacted at 100° C. for 2 days
2. extractionThen it was extracted by EA and brine
3. washwashed by brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. custompurified by flash chromatography, (PE: EA=10:1 to 3:1)