反应详情

1-fluoro-4-nitrobenzene (3.0 g 21.26 mmol), piperidin-4-ol (2.26 g, 22.32 mmol), K2CO3 (4.4 g, 31.89 mmol) was mixed in 20 mL DMF, reacted at 80° C. for 2.5 hours. Then the mixture was extracted by EA and brine, washed by brine and then water, dried over Na2SO4, concentrated. The crude product was used directly in the next step without further purification.

1. customreacted at 80° C. for 2.5 hours
2. extractionThen the mixture was extracted by EA and brine
3. washwashed by brine
4. dry with materialwater, dried over Na2SO4
5. concentrationconcentrated
6. customThe crude product was used directly in the next step without further purification