反应详情

温度

100 °C

A mixture of methyl 4-fluoro-2-methoxy-5-nitrobenzoate 8.57 g, 2-cyclohexylimidazole 5.61 g, potassium carbonate 10.34 g and N,N-dimethylacetamide 75 mL was heated at 100° C. for 5 hours in nitrogen atmosphere. The reaction liquid was diluted with ethyl acetate, poured in water and the organic layer was separated. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation to provide 13.52 g of the title compound.

1. customThe reaction liquid
2. customthe organic layer was separated
3. washThe organic layer was washed with brine
4. dry with materialdried over magnesium sulfate
5. customremoved of the solvent by distillation