Tetrahydrofuran → HCID 67233330, compound

HRID 578063Notes

Reaction equation

HRID 578063 reaction equation
[NH2:1][C:2]1[C:17]([N+:18]([O-])=O)=[CH:16][C:5]([C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:7])=[C:4]([O:21][CH:22]2[CH2:26][CH2:25][O:24][CH2:23]2)[CH:3]=1.C1COCC1>[Pt].CO>[NH2:1][C:2]1[C:17]([NH2:18])=[CH:16][C:5]([C:6]([O:8][CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:7])=[C:4]([O:21][CH:22]2[CH2:26][CH2:25][O:24][CH2:23]2)[CH:3]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 67233430HCID 67233430, compound

Product 1

HCID 67233330HCID 67233330, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

Platinum on charcoal (100 mg 5%) was added to the product obtained at (659b) (160 mg, 0.45 mmol) in 10 mL methanol with 5 mL THF and the mixture was hydrogenated at 4 bar H2 pressure at ambient temperature for 5 h. The mixture was filtered, washed with methanol and the filtrate concentrated i. vac. The product was reacted without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. washwashed with methanol
  3. concentrationthe filtrate concentrated i
  4. customThe product was reacted without further purification

Sources & evidence

ORD record
ord-824af92cc3ab437e8a1d2b91ef134b78
Source dataset
uspto-grants-2015_05
Patent number
US09040565B2

Reaction notes

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