Hydrochloric Acid → HCID 14180893, compound

HRID 579841Notes

Reaction equation

HRID 579841 reaction equation
[ClH:1].[OH:2][CH:3]([CH:17]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:4][N:5](CC(C)C)[CH2:6][C:7]1[CH:12]=CC=C[CH:8]=1.Cl>CO.[OH-].[OH-].[Pd+2]>[ClH:1].[OH:2][CH:3]([C@@H:17]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:26])[CH3:27])[CH2:18][CH:19]([CH3:20])[CH3:21])[CH2:4][NH:5][CH2:6][CH:7]([CH3:12])[CH3:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131715572HCID 131715572, compound

Product 1

HCID 14180893HCID 14180893, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

1-[(RS)-1-Hydroxy-2-[(2-methylpropyl)(phenylmethyl)amino]ethyl]-3-methylbutylcarbamic acid, 1,1-dimethylethyl ester, hydrochloride (1.67 g, 4.25 mmol) was dissolved in methanol (50 ml) and hydrochloric acid (1N, 4.25 ml) was added. The solution was stirred under an atmosphere of hydrogen in the presence of palladium hydroxide on carbon catalyst (0.36 g) for two hours. It was filtered through Hyflo and concentrated to dryness in vacuo (1.31 g).

Workup

  1. filtrationIt was filtered through Hyflo
  2. concentrationconcentrated to dryness in vacuo (1.31 g)

Sources & evidence

ORD record
ord-a9751e09a14e4d188f2a038e6dda980e
Source dataset
uspto-grants-1988_06
Patent number
US04749792

Reaction notes

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