反应详情

Vanillin (16.3 g, 0.107 mole), ethyl bromoacetate (21.6 g, 0.128 mole), potassium carbonate (17.8 g, 0.128 mole) and N,N-dimethyl-formamide (75 ml) were united, stirred and heated at 50°-55° C. for 35 minutes. Then a 10% aqueous sodium hydroxide solution (100 ml) and water (300 ml) was added and the mixture stirred on a steam bath for one hour. The solution was cooled and acidified with hydrochloric acid. The solid that separated was removed by filtration, washed with water and dried to give 20.4 g of the desired product, m.p. 177°-178° C.

1. temperatureheated at 50°-55° C. for 35 minutes
2. stirringthe mixture stirred on a steam bath for one hour
3. temperatureThe solution was cooled
4. customThe solid that separated
5. customwas removed by filtration
6. washwashed with water
7. customdried