Piperidine → Piperidine, 1-(2-phenoxyethyl)-

HRID 580105Notes

Reaction equation

HRID 580105 reaction equation
[O:1]([CH2:8][CH2:9]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[O:1]([CH2:8][CH2:9][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 68526Benzene, (2-bromoethoxy)-

Product 1

HCID 120169Piperidine, 1-(2-phenoxyethyl)-Yield 96.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 20 g of 2-phenoxyethyl bromide thus obtained, 7.92 g of piperidine and 12.86 g of potassium carbonate was added into 100 ml of ethyl alcohol and stirred for 6 hours at 100° C. The reaction mixture was filtered and condensed under reduced pressure to give 18.4 g of 1-(2-phenoxyethyl)piperidine having a boiling point of 111° C. to 112° C. at 7 mmHg in a yield of 90%.

Workup

  1. customthus obtained
  2. filtrationThe reaction mixture was filtered
  3. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-f91f00d08a8c436c8afd3b84dc37f311
Source dataset
uspto-grants-1988_06
Patent number
US04751302

Reaction notes

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