4-Methoxybenzylamine → HCID 54264880, compound

HRID 580825Notes

Reaction equation

HRID 580825 reaction equation
Cl[C:2]1[C:7]([C:8]2[N:9]=[CH:10][S:11][C:12]=2[C:13]2[C:14]([Cl:19])=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:20][O:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>C1(C)C(C)=CC=CC=1>[CH3:20][O:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH:27][C:2]2[C:7]([C:8]3[N:9]=[CH:10][S:11][C:12]=3[C:13]3[C:14]([Cl:19])=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:6][CH:5]=[CH:4][N:3]=2)=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 754524-MethoxybenzylamineHCID 53662505HCID 53662505, compound

Product 1

HCID 54264880HCID 54264880, compoundYield 24.1%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 4,5-di-(2-chloropyridin-3-yl)thiazole (0.047 g), 4-methoxybenzylamine (0.021 g), and diisopropylethylaamine (0.025 g) in xylene was heated in a sealed tube at 130° C. for 4 days. The solvent was evaporated, and the residue was fractionated by chromatography to give 4-[2-(4-methoxybenzylamino)pyridin-3-yl]-5-(2-chloropyridin-3-yl)thiazole (0.015 g).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-685566fd1b4b449aaee2cb1e809bc8d2
Source dataset
uspto-grants-1999_07
Patent number
US05919779

Reaction notes

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