Butyl nitrite → HCID 53842386, compound

HRID 580826Notes

Reaction equation

HRID 580826 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[N:9]=[C:10](N)[O:11][C:12]=2[C:13]2[C:14]([Cl:19])=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.C(ON=O)CCC>O1CCCC1>[Cl:1][C:2]1[C:7]([C:8]2[N:9]=[CH:10][O:11][C:12]=2[C:13]2[C:14]([Cl:19])=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 10996Butyl nitriteHCID 54463626HCID 54463626, compound

Product 1

HCID 53842386HCID 53842386, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4, 5-di-(2-chloropyridin-3-yl)-2-aminooxazole (0.030 g) in tetrahydrofuran (3 mL) was added butylnitrite (0.033 g). The mixture was heated under reflux for 3 hours. The solvent was evaporated, and the residue was fractionated by chromatography to give 4, 5-di-(2-chloropyridin-3-yl)oxazole (0.010 g) as a solid. mp 157-158° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-76007b0090464312947d773c401b4e4e
Source dataset
uspto-grants-1999_07
Patent number
US05919779

Reaction notes

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