反应详情

温度

80 °C

To a mixture of 1-(ethoxycarbonyl)piperidin-4-yl methanesulfonate (10 g) and 4-hydroxy benzaldehyde (5.8 g) in dry DMF (75 ml), K2CO3 (11 g) was added and the mixture was stirred at 80° C. for 12 h. At the end of this time, the reaction mixture was cooled, added water and extracted with EtOAc. The EtOAc extract was washed with 5% aqueous Na2CO3 solution followed by brine and dried over anhydrous sodium sulphate. The solvent was then removed by distillation under reduced pressure to give 7 g (63.6%) of the title compound as a semi solid.

1. additionwas added
2. temperatureAt the end of this time, the reaction mixture was cooled
3. extractionextracted with EtOAc
4. extractionThe EtOAc extract
5. washwas washed with 5% aqueous Na2CO3 solution
6. dry with materialdried over anhydrous sodium sulphate
7. customThe solvent was then removed by distillation under reduced pressure