Triethylamine → HCID 54556780, compound

HRID 580921Notes

Reaction equation

HRID 580921 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[O:27])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:16][CH:15]1[OH:28].[CH3:29][S:30](Cl)(=[O:32])=[O:31].C(N(CC)CC)C>C1COCC1>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[O:27])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:16][CH:15]1[O:28][S:30]([CH3:29])(=[O:32])=[O:31]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 67594327HCID 67594327, compound

Product 1

HCID 54556780HCID 54556780, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of the alcohol 67 (1 mmole) in THF is cooled to 0° C. Methanesulfonyl chloride (1 mmole) and triethylamine (1 mmole) are added and the solution is stirred at 0° C. for 6 hr. Standard work-up and flash chromatography affords 68.

Sources & evidence

ORD record
ord-3f2baf8cbad5402984dc274555748e9d
Source dataset
uspto-grants-1999_07
Patent number
US05919797

Reaction notes

Loading…