反应详情

温度

80 °C

A mixture of 1-ethyl-piperazine (1.2 mL, 9.6 mmol), 5-fluoro-2-nitro-phenylamine (1 g, 6.4 mmol), DIPEA (1.24 g, 9.6 mmol) in DMF (15 mL) was heated at 80° C. overnight. The reaction mixture was poured into ice water and extracted with EtOAc. The combined extract was washed with brine, dried over anhydrous Na2SO4, and concentrated to obtain a crude product, which was purified by flash chromatography on silica to afford the title compound (1 g, yield: 63%). ESI-MS: 251 [M+H]+.

1. extractionextracted with EtOAc
2. extractionThe combined extract
3. washwas washed with brine
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated
6. customto obtain a crude product, which
7. customwas purified by flash chromatography on silica