Chloride → HCID 54079837, compound

HRID 582461Notes

Reaction equation

HRID 582461 reaction equation
[Cl-].[C:2]([NH:6][S:7]([C:10]1[CH:15]=[C:14]([CH2:16][NH:17][CH3:18])[CH:13]=[CH:12][C:11]=1[S:19]([CH3:22])(=[O:21])=[O:20])(=[O:9])=[O:8])([CH3:5])([CH3:4])[CH3:3].C(N(CC)CC)C>ClCCl>[C:2]([NH:6][S:7]([C:10]1[CH:15]=[C:14]([CH2:16][N:17]([CH3:18])[S:7]([CH3:10])(=[O:9])=[O:8])[CH:13]=[CH:12][C:11]=1[S:19]([CH3:22])(=[O:21])=[O:20])(=[O:8])=[O:9])([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 312ChlorideHCID 8471TriethylamineHCID 54146006HCID 54146006, compound

Product 1

HCID 54079837HCID 54079837, compoundYield 179.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

0.39 ml (5 mmol) of methenesulfonyl chloride dissolved in 5 ml of dichloromethane are added dropwise to a solution of 1.67 g (5 mmol) of N-tert-butyl-5-methylaminomethyl-2-methanesulfonylbenzenesulfonamide and 0.73 ml (5.3 mmol) of triethylamine in 20 ml of dichloromethane which had been cooled to 0° C. After 30 min at room temperature, the reaction solution is washed with water, dried and completely evaporated in vacuo. 1.85 g (89.7%) of N-tert-butyl-5-(N-methyl-N-methanesulfonylaminomethyl)-2-methanesulfonylbenzenesulfonamide are obtained as a viscous oil.

Workup

  1. washthe reaction solution is washed with water
  2. customdried
  3. customcompletely evaporated in vacuo

Sources & evidence

ORD record
ord-acb46a44d0c84ea3b7996489567e793e
Source dataset
uspto-grants-1999_07
Patent number
US05925596

Reaction notes

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