Triethylamine → N-(2-Methylcyclohex-1-yl)-1-(3-chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxamide

HRID 582926Notes

Reaction equation

HRID 582926 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH2:8].C(N(CC)CC)C.[Cl:16][C:17]1[CH:18]=[C:19]([CH:37]=[CH:38][C:39]=1[CH3:40])[CH2:20][N:21]1[C:25]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)=[CH:24][C:23]([C:34](Cl)=[O:35])=[N:22]1>C(Cl)Cl>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8][C:34]([C:23]1[CH:24]=[C:25]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)[N:21]([CH2:20][C:19]2[CH:37]=[CH:38][C:39]([CH3:40])=[C:17]([Cl:16])[CH:18]=2)[N:22]=1)=[O:35]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 234322-MethylcyclohexylamineHCID 540952651-(3-Chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxylic acid chloride

Product 1

HCID 53722250N-(2-Methylcyclohex-1-yl)-1-(3-chloro-4-methylbenzyl)-5-(3,4-dichlorophenyl)pyrazole-3-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

This compound is prepared by the procedure described in step B of EXAMPLE 36 from 1 ml of 2-methylcyclohexylamine, 1 ml of triethylamine in 15 ml of DCM and 1.5 g of the compound obtained in step A of EXAMPLE 36 in 15 ml of DCM. The compound is purified by chromatography on silica using a DCM/MeOH mixture (98/2; v/v) as the eluent to give 0.27 g of the expected product. M.p.=165° C.

Workup

  1. customThis compound is prepared by the procedure
  2. customThe compound is purified by chromatography on silica using a DCM/MeOH mixture (98/2; v/v) as the eluent

Sources & evidence

ORD record
ord-7df87266b2ea4008874eef01edf3aabf
Source dataset
uspto-grants-1999_07
Patent number
US05925768

Reaction notes

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