4-Isopropylaniline → HCID 86754321, compound

HRID 583401Notes

Reaction equation

HRID 583401 reaction equation
[CH3:1][N:2]([CH:19]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=1)[CH2:20][CH2:21][C:22]([OH:24])=O)[C:3](=[O:18])[C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1.[CH:33]([C:36]1[CH:42]=[CH:41][C:39]([NH2:40])=[CH:38][CH:37]=1)([CH3:35])[CH3:34].C(N(CC)CC)C.C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[CH:33]([C:36]1[CH:42]=[CH:41][C:39]([NH:40][C:22](=[O:24])[CH2:21][CH2:20][CH:19]([N:2]([CH3:1])[C:3](=[O:18])[C:4]2[CH:5]=[C:6]([C:14]([F:16])([F:15])[F:17])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[CH:9]=2)[CH2:25][C:26]2[CH:27]=[CH:28][C:29]([Cl:32])=[CH:30][CH:31]=2)=[CH:38][CH:37]=1)([CH3:35])[CH3:34]

Participants

6

Reactant 4

HCID 74644-IsopropylanilineHCID 8471TriethylamineHCID 11430Potassium CarbonateHCID 54312120HCID 54312120, compound

Product 1

HCID 86754321HCID 86754321, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture consisting of 41.6 mg of 4-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(4-chlorophenyl)-pentanoic acid, 12.8 mg of 4-isopropylaniline, 36.65 mg of propanephosphonic acid anhydride, 37 mg of triethylamine and 1.5 ml of methylene chloride is left to stand at room temperature for 18 hours. 0.5 ml of 1N potassium carbonate solution is then added and the mixture is shaken vigorously. After separation of the phases, the organic phase is separated off and concentrated by evaporation. In this way the title compound is obtained in the form of a white foam. Rf value=0.26 (ethyl acetate)

Workup

  1. waitis left
  2. customAfter separation of the phases
  3. customthe organic phase is separated off
  4. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-ebd41e6e051f447eba922135f6d0e34e
Source dataset
uspto-grants-1999_07
Patent number
US05929067

Reaction notes

Loading…