Diisopropylethylamine → HCID 22343051, compound

HRID 584131Notes

Reaction equation

HRID 584131 reaction equation
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[NH:5][N:4]=1.[NH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:34])[CH2:19][CH2:20][C:21]1[O:25][N:24]=[C:23]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[N:22]=1.CCN(C(C)C)C(C)C>CN(C=O)C>[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:26]([C:23]2[N:22]=[C:21]([CH2:20][CH2:19][C:18]([NH:17][CH2:16][CH2:15][NH:14][CH2:2][C:3]3[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[C:6](=[O:13])[NH:5][N:4]=3)=[O:34])[O:25][N:24]=2)=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 22343088HCID 22343088, compoundHCID 22343439HCID 22343439, compound

Product 1

HCID 22343051HCID 22343051, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-chloromethyl-2H-phthalazin-1-one (9.7 mg, 0.05 mmol) in DMF (200 μL), N-(2-amino-ethyl)-3-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-propionamide (14.4 mg, 0.05 mmol) and DIPEA (9 μL, 0.05 mmol) were added. The mixture was stirred overnight at rt and directly applied to preparative HPLC. The purity was determined by RPLC/MS.

Sources & evidence

ORD record
ord-9a25e25318c94fdea5cdd8d2e2184e8b
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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