Potassium Carbonate → HCID 9907539, compound

HRID 584655Notes

Reaction equation

HRID 584655 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([SH:13])[C:6]([CH:14]([CH3:16])[CH3:15])=[N:5]2.C(=O)([O-])[O-].[K+].[K+].Br[CH2:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>CN(C=O)C>[CH2:29]([O:28][C:26](=[O:27])[CH2:25][CH2:24][S:13][C:7]1[C:6]([CH:14]([CH3:16])[CH3:15])=[N:5][C:4]2[C:9](=[CH:10][C:11]([Cl:12])=[C:2]([Cl:1])[CH:3]=2)[N:8]=1)[CH3:30]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68320Ethyl 3-bromopropionateHCID 178439934HCID 178439934, compound

Product 1

HCID 9907539HCID 9907539, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 6,7-dichloro-3-isopropylquinoxaline-2-thiol (36 mg, 0.13 mmol) in DMF was added potassium carbonate (55 mg, 0.40 mmol) followed by ethyl 3-bromopropionate (0.02 ml, 0.16 mmol). The reaction was stirred at room temperature for 4 days. Purification by flash column chromatography using ethyl acetate:hexanes 1:40 afforded the title compound.

Workup

  1. customPurification by flash column chromatography

Sources & evidence

ORD record
ord-8ef5925c10404b01aecd7b6dafd3f8a4
Source dataset
uspto-grants-2005_08
Patent number
US06927214B1

Reaction notes

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