Benzaldehyde → HCID 9796853, compound

HRID 586596Notes

Reaction equation

HRID 586596 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7]([N+:11]#[C-:12])([CH3:10])([CH3:9])[CH3:8].[CH:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:21](Cl)(=[O:23])[CH3:22]>Cl(O)(=O)(=O)=O>[C:7]([N:11]([C:12]1[N:6]2[C:2]([S:3][CH:4]=[CH:5]2)=[N:1][C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:21](=[O:23])[CH3:22])([CH3:10])([CH3:9])[CH3:8]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 21552-AminothiazoleHCID 6367Acetyl chlorideHCID 23577Tert-Butyl isocyanide

Product 1

HCID 9796853HCID 9796853, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 40 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-aminothiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) and by reaction with acetyl chloride, the excess acetyl chloride being removed in vacuo.

Workup

  1. customthe excess acetyl chloride being removed in vacuo

Sources & evidence

ORD record
ord-7333c01d1d1242daad5c132b72604e26
Source dataset
uspto-grants-2005_08
Patent number
US06936631B2

Reaction notes

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