反应详情

(S)-3-((R)-2-Ethyl-1-hydroxybutyl)pyrrolidine-1-carboxylic acid t-butyl ester (28 mg, 0.1 mmol) was dissolved in DMF (380 μL, 4.9 mmol). 60% Sodium hydride in oil (0.4:0.6, sodium hydride:mineral oil, 18.6 mg, 310 μmol) was slowly added, and the resulting mixture was stirred at room temperature for 15 minutes. 1,2-Dichloro-3-fluorobenzene (23.8 μL, 206 μmol) was added and the mixture was stirred at 70° C. for 3 hours. The mixture was concentrated, treated with 1.25M HCl in EtOH (578 μL, 722 μmol), then stirred overnight at room temperature. The product was concentrated under vacuum, redissolved in 1:1AcOH:H2O, filtered, and purified by preparative HPLC to yield the title compound as a mono-TFA salt (5.3 mg, 97% purity). MS m/z: [M+H] calcd for C16H23Cl2NO, 316.12. found 316.3.

1. stirringthe mixture was stirred at 70° C. for 3 hours
2. concentrationThe mixture was concentrated
3. stirringstirred overnight at room temperature
4. concentrationThe product was concentrated under vacuum
5. dissolutionredissolved in 1:1AcOH
6. filtrationH2O, filtered
7. custompurified by preparative HPLC