Triethylamine → HCID 67294821, compound

HRID 589189Notes

Reaction equation

HRID 589189 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([NH2:11])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.C(N(CC)CC)C.Cl[C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([NH:11][C:20](=[O:21])[O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:9][CH2:10]2)=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 10387Benzyl chloroformateHCID 573568181-(5-Bromopyridin-2-yl)cyclopropanamine

Product 1

HCID 67294821HCID 67294821, compound

Procedure

At 0° C., to the mixture of 1-(5-bromopyridin-2-yl)cyclopropanamine (1.07 g, 5.0 mmol), triethylamine (766 ul, 5.5 mmol) was added benzyl chloroformate (785 ul, 5.5 mmol). The resulting mixture was allowed to stir at it for 1 h. After work up, the crude product was purified by column chromatography on SiO2.

Workup

  1. customAfter work up, the crude product was purified by column chromatography on SiO2

Sources & evidence

ORD record
ord-387dd3a1ae514f7eba8594e703581027
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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