反应详情

温度

60 °C

A mixture of 1.10 g of 2-fluoro-3-(trifluoromethyl)benzaldehyde, 663 mg of methyl thioglycolate, 1.03 g of potassium carbonate and 15 ml of DMF was stirred at 60° C. for 2 hours. The reaction mixture was cooled to room temperature. To the reaction mixture was added water, and then extracted with tert-butyl methyl ether 3 times. The combined organic layer was washed with water, followed by saturated aqueous sodium chloride solution. The mixture was dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 1.34 g of methyl 7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted with tert-butyl methyl ether 3 times
3. washThe combined organic layer was washed with water
4. dry with materialThe mixture was dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure