Dodecylamine → Laurylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

HRID 589290Notes

Reaction equation

HRID 589290 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:14]=[CH:13][C:6]2[S:7][C:8]([C:10]([OH:12])=[O:11])=[CH:9][C:5]=2[CH:4]=1.[CH2:17]([NH2:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>COC(C)(C)C>[F:16][C:2]([F:1])([F:15])[C:3]1[CH:14]=[CH:13][C:6]2[S:7][C:8]([C:10]([O-:12])=[O:11])=[CH:9][C:5]=2[CH:4]=1.[CH2:17]([NH3+:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

4

Reactant 2

HCID 13583DodecylamineHCID 27830435-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid

Product 1

HCID 70982284Laurylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylateYield 102.3%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

A mixture of 300 mg of 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, 238 mg of laurylamine and 10 ml of tert-butyl methyl ether was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 538 mg of laurylammonium 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (hereinafter referred to as “the present compounds 8”).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-09e727217a354c048c071e408deddb07
Source dataset
uspto-grants-2016_01
Patent number
US09232792B2

Reaction notes

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