反应详情

Ethyl 2-[3-[4-(4-chlorobenzamido)benzyl]-1H-indazol-1-yl]acetate (100 mg, 0.223 mmol) was dissolved in 3 mL tetrahydrofuran, and 1 mL methanol, 3 mL water were added. In an ice bath was, 47 mg (1.12 mmol) lithium hydroxide monohydrate was added. I was moved to be at room temperature and reacted for 10 minutes. The reaction was monitored to be complete by TLC. Diluted hydrochloric acid was added to adjust pH to be acidic. Water was added, pumping filtered, dried to obtain a white solid 70 mg, at a yield of 74.9%

1. customIn an ice bath was
2. customto be at room temperature
3. customreacted for 10 minutes
4. filtrationpumping filtered
5. customdried