Sodium sulfate decahydrate → HCID 18673047, compound

HRID 591496Notes

Reaction equation

HRID 591496 reaction equation
[CH:1]([C:4]1[S:5][C:6]([C:10](OCC)=[O:11])=[C:7]([CH3:9])[N:8]=1)([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[CH:1]([C:4]1[S:5][C:6]([CH2:10][OH:11])=[C:7]([CH3:9])[N:8]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 62649Sodium sulfate decahydrateHCID 21226445Aluminium lithium hydrideHCID 23560694HCID 23560694, compound

Product 1

HCID 18673047HCID 18673047, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of ethyl 2-isopropyl-4-methyl-1,3-thiazole-5-carboxylate (2.42 g) in THF (50 mL) was added lithium aluminum hydride (0.431 g) at 0° C. The mixture was stirred at 0° C. under argon atmosphere for 1 h. To the mixture was added sodium sulfate decahydrate and the mixture was stirred for 10 min. The precipitate was filtered off through celite and the filtrate was concentrated in vacuo to give the title compound (1.9 g).

Workup

  1. stirringthe mixture was stirred for 10 min
  2. filtrationThe precipitate was filtered off through celite
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-3d99c9a77b05462fa20cd5150ca070d7
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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