Oxalyl chloride → 2-Fluoro-4-(trifluoromethyl)benzoyl isocyanate

HRID 59343Notes

Reaction equation

HRID 59343 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)CCl>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:3]=1[C:4]([N:6]=[C:16]=[O:17])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 6056892-Fluoro-4-(trifluoromethyl)benzamide

Product 1

HCID 900197172-Fluoro-4-(trifluoromethyl)benzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 2-fluoro-4-(trifluoromethyl)benzamide (0.200 g, 0.96 mmol), EDC (10 mL) and oxalyl chloride (0.1 mL, 1.15 mmol) to afford 0.200 g of the product.

Sources & evidence

ORD record
ord-70a41fa265ea4ec0ad3939d56ba4abb6
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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