Oxalyl chloride → 3-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzoyl isocyanate

HRID 59355Notes

Reaction equation

HRID 59355 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10]([NH2:12])=[O:11])=[O:4].C(Cl)(=O)[C:21](Cl)=[O:22]>C(Cl)CCl>[F:1][C:2]([F:18])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10]([N:12]=[C:21]=[O:22])=[O:11])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 900191333-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

Product 1

HCID 900192983-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 3-((2,2,2-trifluoroacetamido)methyl)-2,6-dimethylbenzamide (1.0 g, 3.6 mmol), oxalyl chloride and EDC (10 mL) to afford 0.900 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5ff782c0471f46efab3756600b21d4dd
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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