Oxalyl chloride → 4-Fluoro-3-(trifluoromethyl)benzoyl isocyanate

HRID 59405Notes

Reaction equation

HRID 59405 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)CCl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:16]=[O:17])=[O:7])=[CH:4][C:3]=1[C:11]([F:12])([F:13])[F:14]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 1442544-Fluoro-3-(trifluoromethyl)benzamide

Product 1

HCID 900192954-Fluoro-3-(trifluoromethyl)benzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 4-fluoro-3-(trifluoromethyl)benzamide (0.200 g), oxalyl chloride (0.012 mL) and EDC (15 mL) to afford 0.150 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-f307a7d3412647da9c443a172da55893
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Reaction notes

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