Lithium Hydroxide → HCID 66801117, compound

HRID 594945Notes

Reaction equation

HRID 594945 reaction equation
[C:1]([N:5]1[C:13]2[CH2:12][CH2:11][C:10]([CH3:18])([C:14]([O:16]C)=[O:15])[CH2:9][C:8]=2[C:7]([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1>[C:1]([N:5]1[C:13]2[CH2:12][CH2:11][C:10]([CH3:18])([C:14]([OH:16])=[O:15])[CH2:9][C:8]=2[C:7]([C:19]2[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=2)=[N:6]1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86689213HCID 86689213, compound

Product 1

HCID 66801117HCID 66801117, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

To methyl 1-tert-butyl-5-methyl-3-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indazole-5-carboxylate (1.1 g, 3.5 mmol) in THF (20 mL) was added LiOH (1 M, 10 mL, 10 mmol) and the reaction was heated at 80° C. for overnight. After removal of THF, HCl (1 N) was added until pH˜4 to 5. The product precipitated as white solid and was collected by filtration (1.0 g). LC-MS found 314.19 (M+H)

Workup

  1. customAfter removal of THF, HCl (1 N)
  2. additionwas added until pH˜4 to 5
  3. customThe product precipitated as white solid
  4. filtrationwas collected by filtration (1.0 g)

Sources & evidence

ORD record
ord-98d5235a107a425d9f268e442d821af0
Source dataset
uspto-grants-2016_01
Patent number
US09242981B2

Reaction notes

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