反应详情

To methyl 3-(5-amino-6-(3-fluoro-4-(methoxycarbonyl)phenyl)pyrazin-2-yl)piperidine-1-carboxylate (50 mg, 0.129 mmol) in THF (4 mL) and MeOH (2 mL) was added 1 M LiOH (0.500 mL, 0.500 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture pH was adjusted to ˜3 with 2 N HCl, and product was extracted with ethyl acetate. The EtOAc layer was separated, washed with brine, dried over sodium sulfate, filtered and evaporated. The residue was proceeded to next step without purification (40 mg, 83%). LCMS (m/z): 375.2 (MH+), 0.637 min.

1. extractionwas extracted with ethyl acetate
2. customThe EtOAc layer was separated
3. washwashed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customevaporated
7. customThe residue was proceeded to next step without purification (40 mg, 83%)
8. custom375.2 (MH+), 0.637 min.