Hydrochloric Acid → 4-(6-(1-Acetylpiperidin-3-yl)-3-aminopyrazin-2-yl)-2-fluorobenzoic acid

HRID 596096Notes

Reaction equation

HRID 596096 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]2[N:15]=[C:14]([C:16]3[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[C:18]([F:26])[CH:17]=3)[C:13]([NH2:27])=[N:12][CH:11]=2)[CH2:5]1)(=[O:3])[CH3:2].[Li+].[OH-].Cl>C1COCC1.CO>[C:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]2[N:15]=[C:14]([C:16]3[CH:25]=[CH:24][C:19]([C:20]([OH:22])=[O:21])=[C:18]([F:26])[CH:17]=3)[C:13]([NH2:27])=[N:12][CH:11]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 118045778Methyl 4-(6-(1-acetylpiperidin-3-yl)-3-aminopyrazin-2-yl)-2-fluorobenzoate

Product 1

HCID 1180459824-(6-(1-Acetylpiperidin-3-yl)-3-aminopyrazin-2-yl)-2-fluorobenzoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of methyl 4-(6-(1-acetylpiperidin-3-yl)-3-aminopyrazin-2-yl)-2-fluorobenzoate (50 mg, 0.134 mmol) in THF (4 mL) and MeOH (2 mL) was added 1 M LiOH (0.500 mL, 0.500 mmol). The reaction mixture was stirred at room temperature for 4 h. The pH of reaction mixture was adjusted to ˜3 with 2 N HCl, and the product was extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over sodium sulfate, filtered and evaporated. The residue was proceeded for next step without purification (34 mg, 70.7%). LCMS (m/z): 359.1 (MH+), 0.534 min.

Workup

  1. customThe pH of reaction mixture
  2. extractionthe product was extracted with ethyl acetate
  3. customThe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue was proceeded for next step without purification (34 mg, 70.7%)
  9. custom359.1 (MH+), 0.534 min.

Sources & evidence

ORD record
ord-834bce8fda924b2ba5b7353b5f141803
Source dataset
uspto-grants-2016_01
Patent number
US09242996B2

Reaction notes

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