4-Toluenesulfonyl chloride → HCID 21450857, compound

HRID 596403Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[C:22]([CH2:23][N:24]([CH3:26])[CH3:25])=[N:21][N:20]=[C:19]2[CH2:27]O)=[C:6]([CH:17]=1)[C:7]([C:9]1[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])=[O:8].C1(C)C=CC(S(Cl)(=O)=O)=CC=1.[CH2:40]([NH2:43])[C:41]#[CH:42]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[C:22]([CH2:23][N:24]([CH3:26])[CH3:25])=[N:21][N:20]=[C:19]2[CH2:27][NH:43][CH2:40][C:41]#[CH:42])=[C:6]([CH:17]=1)[C:7]([C:9]1[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])=[O:8]

Participants

Reactant 3

HCID 73974-Toluenesulfonyl chloride

HCID 239041Propargylamine

HCID 21450805HCID 21450805, compound

Product 1

HCID 21450857HCID 21450857, compound

Procedure

In the manner given in Example 47, 5-chloro-2',6'-difluoro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with p-toluenesulfonyl chloride followed by propargylamine, to give 5-chloro-2',6'-difluoro-2-[3-[[(2-propynyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-3135e56a0fc7490b91e1cd8ff61b1728
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010177

Reaction notes

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