反应详情

A solution of 7.5 g. of 2-benzyloxyethanol in 30 ml. of dimethylformamide is treated with 1.2 g. of sodium hydride. When the mixture is homogeneous, 3.5 g. of 2-amino-4-chloro-1-nitrobenzene is added and the mixture heated at 110°-120° for 4 hours. The mixture is cooled, diluted with water and extracted with benzene. The crude product is treated with charcoal and isolated by precipitation with cyclohexane to afford 2-amino-1-nitro-4-(2-benzyloxyethoxy)benzene.

1. temperaturethe mixture heated at 110°-120° for 4 hours
2. temperatureThe mixture is cooled
3. extractionextracted with benzene
4. additionThe crude product is treated with charcoal
5. customisolated by precipitation with cyclohexane