Hydrochloric Acid → HCID 21449358, compound

HRID 597037Notes

Reaction equation

HRID 597037 reaction equation
[C:1]1([N:7]([C:9]2[CH:14]=[C:13]([Cl:15])[N:12]=[C:11]([Cl:16])[N:10]=2)N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])=O.Cl>O>[Cl:16][C:11]1[N:10]=[C:9]([N:7]2[C:1]3[C:6](=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:20]([CH2:21][C:22]([OH:24])=[O:23])=[C:18]2[CH3:17])[CH:14]=[C:13]([Cl:15])[N:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11579Levulinic AcidHCID 21449354HCID 21449354, compound

Product 1

HCID 21449358HCID 21449358, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of N-phenyl-N-(2,6-dichloropyrimidin-4-yl)hydrazine (30g.) and laevulinic acid (50g.) was heated at 100° C. for 3 hours whilst a stream of hydrogen chloride gas was passed through it. The mixture was cooled and added to water (400ml.), and the resulting mixture filtered to give 1-(2,6-dichloropyrimidin-4-yl)-2-methylindol-3-ylacetic acid, m.p. 205°-207° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe resulting mixture filtered

Sources & evidence

ORD record
ord-8c8fc3c390864071a3bbc2c613908dd3
Source dataset
uspto-grants-1977_03
Patent number
US04012513

Reaction notes

Loading…