Hydrochloric Acid → N-((4-(((4-bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride

HRID 59792Notes

Reaction equation

HRID 59792 reaction equation
[C:1]([NH:4][S:5]([C:8]1[CH:37]=[CH:36][C:11]([CH2:12][N:13]([CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][CH:30]=2)[CH:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1)(=[O:7])=[O:6])(=[O:3])[CH3:2].[ClH:38]>CCOC(C)=O>[ClH:38].[Br:35][C:32]1[CH:33]=[CH:34][C:29]([CH2:28][CH2:27][N:13]([CH2:12][C:11]2[CH:36]=[CH:37][C:8]([S:5]([NH:4][C:1](=[O:3])[CH3:2])(=[O:7])=[O:6])=[CH:9][CH:10]=2)[CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 121410336HCID 121410336, compound

Product 1

HCID 121410314N-((4-(((4-bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 4-((4-(N-acetylsulfamoyl)benzyl)(4-bromophenethyl)amino)piperidine-1-carboxylate obtained in Step 1 was subjected to the deprotection reaction as described in Procedure 2 (4 N HCl in EtOAc). The crude product was carried on to the next step without further purification.

Workup

  1. customThe crude product was carried on to the next step without further purification

Sources & evidence

ORD record
ord-4c2f6e14737443418775cf70074460c6
Source dataset
uspto-grants-2016_09
Patent number
US09440953B2

Reaction notes

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