Potassium Carbonate → HCID 178475154, compound

HRID 59793Notes

Reaction equation

HRID 59793 reaction equation
Cl.[Br:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][CH2:8][N:9]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27](=[O:29])[CH3:28])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.C([O-])([O-])=O.[K+].[K+].[C:38]([N:40]=[C:41]([N:43]1CCNCC1)[S-])#[N:39].O.[NH2:50]N>>[NH2:50][C:41]1[N:40]=[C:38]([N:13]2[CH2:14][CH2:15][CH:10]([N:9]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27](=[O:29])[CH3:28])(=[O:25])=[O:24])=[CH:19][CH:18]=3)[CH2:8][CH2:7][C:6]3[CH:30]=[CH:31][C:3]([Br:2])=[CH:4][CH:5]=3)[CH2:11][CH2:12]2)[NH:39][N:43]=1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 24654Hydrazine hydrate (1:1)HCID 121410314N-((4-(((4-bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochlorideHCID 131737066N-cyanopiperazine-1-carbimidothioate

Product 1

HCID 178475154HCID 178475154, compound

Procedure

N-((4-(((4-Bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride obtained in Step 2 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3.

Sources & evidence

ORD record
ord-d1c81bf415924904b5e3a8cac6d77f51
Source dataset
uspto-grants-2016_09
Patent number
US09440953B2

Reaction notes

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