反应详情

5-Bromo-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinic acid ethyl ester (4.0 g, 10 mmol) was dissolved in a mixture of tetrahydrofuran (70 mL) and water (25 mL). Lithiumhydroxid monohydrate (1.26 g, 30 mmol) was added and the mixture was stirred and heated at reflux-temperature for 3 h. After cooling to room temperature the mixture was acidified with hydrochloric acid (1N) to pH 4. The product precipitated and was after filtration dried and isolated as a white solid (quant.); MS (ISP) 365.8, 367.8 (M−H).

1. temperatureheated
2. temperatureat reflux-temperature for 3 h
3. customThe product precipitated
4. filtrationafter filtration
5. customdried
6. customisolated as a white solid (quant.)