Dimethylformamide → 1,3,6-Tri(4-methylphenyl)pyrene

HRID 600161Notes

Reaction equation

HRID 600161 reaction equation
Br[C:2]1[C:15]2[C:16]3=[C:17]4[C:12](=[CH:13][CH:14]=2)[CH:11]=[CH:10][C:9](Br)=[C:8]4[CH:7]=[CH:6][C:5]3=[C:4](Br)[CH:3]=1.[CH3:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].CN(C)C=O>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([C:2]2[C:15]3[C:16]4=[C:17]5[C:12](=[CH:13][CH:14]=3)[CH:11]=[CH:10][C:9]([C:2]3[CH:15]=[CH:16][C:5]([CH3:6])=[CH:4][CH:3]=3)=[C:8]5[CH:7]=[CH:6][C:5]4=[C:4]([C:11]3[CH:10]=[CH:9][C:8]([CH3:7])=[CH:17][CH:12]=3)[CH:3]=2)=[CH:23][CH:22]=1

Participants

8

Reactant 4

HCID 6228DimethylformamideHCID 62657Potassium Phosphate, TribasicHCID 79799Tolylboronic acidHCID 30159691,3,6-Tribromopyrene

Product 1

HCID 866285911,3,6-Tri(4-methylphenyl)pyreneYield 167.2%

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 167845palladium(II) acetateCatalystHCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixed solution of 2 g of the above-mentioned 1,3,6-tribromopyrene, 2.5 g of 4-methylphenylboronic acid, 5.8 g of tripotassium phosphate, 0.88 g of tetrabutylammonium bromide, 61 mg of palladium acetate and 137 ml of deaerated dimethylformamide was heated while stirred under nitrogen gas stream at a temperature of 130° C. for 9 hours. After cooling the mixed solution to room temperature, 800 ml of water was injected thereinto to extract therefrom with 200 ml of dichloromethane. The organic layer was washed twice with 100 ml of water, dried by magnesium sulfate and thereafter concentrated by evaporation. The organic layer was purified by silica gel column chromatography and thereafter vacuum dried under a temperature of 70° C. to obtain 1.8 g of 1,3,6-tri(4-methylphenyl)pyrene as pale-yellow powder.

Workup

  1. temperatureAfter cooling the mixed solution to room temperature
  2. extractionto extract
  3. washThe organic layer was washed twice with 100 ml of water
  4. dry with materialdried by magnesium sulfate
  5. concentrationconcentrated by evaporation
  6. customThe organic layer was purified by silica gel column chromatography
  7. customvacuum dried under a temperature of 70° C.

Sources & evidence

ORD record
ord-0d6aab9930a54f03800ebe17ab49de3d
Source dataset
uspto-grants-2011_03
Patent number
US07901794B2

Reaction notes

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