反应详情

4-Chlorobenzaldehyde (45.6 g; 0.325 mol), hydroxylamine hydrochloride (27.9 g; 0.401 mol) and pyridine (64 mL; 0.791 mol) in methylene chloride (600 mL) were stirred overnight at room temperature. The reaction mixture was poured into aqueous hydrochloric acid (2N; 300 mL) and extracted. The organic layer was washed with additional aqueous hydrochloric acid (2×300 mL), water (300 mL), dried (MgSO4), filtered and evaporated to yield oxime 1a as a white solid.

1. extractionextracted
2. washThe organic layer was washed with additional aqueous hydrochloric acid (2×300 mL), water (300 mL)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated