反应详情

The product of Example 358B (0.020 g, 0.04 mmol) in tetrahydrofuran (5 mL) was treated with ammonium formate (13 mg, 0.19 mmole), palladium hydroxide (2 mg) and 10% Pd/C (1 mg) and the resulting mixture was refluxed for 1 hour. The catalyst was filtered off and the filtrate evaporated to give a white solid. The solid residue was partitioned between ethyl acetate (100 mL) and water (5 mL). The layers were separated and the organic solvent was removed under reduced pressure to give the title compound (0.016 g, 100%). MS (ESI−) m/z 413 (M−H)−.

1. temperaturethe resulting mixture was refluxed for 1 hour
2. filtrationThe catalyst was filtered off
3. customthe filtrate evaporated
4. customto give a white solid
5. customThe solid residue was partitioned between ethyl acetate (100 mL) and water (5 mL)
6. customThe layers were separated
7. customthe organic solvent was removed under reduced pressure