Dimethylformamide → HCID 11349506, compound

HRID 601650Notes

Reaction equation

HRID 601650 reaction equation
[H-].[Na+].[F:3][C:4]1[C:9]([N:10]2[C:14]([CH3:15])=[C:13]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[C:21](=[O:25])[CH:20]([O:26][C:27]([CH3:29])=[O:28])[CH2:19]4)[N:12]=[N:11]2)=[CH:8][CH:7]=[CH:6][N:5]=1.[CH3:30]N(C)C=O>CI>[F:3][C:4]1[C:9]([N:10]2[C:14]([CH3:15])=[C:13]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[C:21](=[O:25])[C:20]([CH3:30])([O:26][C:27]([CH3:29])=[O:28])[CH2:19]4)[N:12]=[N:11]2)=[CH:8][CH:7]=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 11439986HCID 11439986, compound

Product 1

HCID 11349506HCID 11349506, compound

Reagents, catalysts & solvents 1

HCID 6328Methyl iodideCatalyst

Procedure

At room temperature, 3 mg of 60% of sodium hydride was added to 1 ml solution of dimethylformamide with 10 mg of 1-(2-fluoropyridine-3-yl)-4-(1-oxo-2-methylcarbonyloxy-indane-5-yl)-5-methyl-1H-[1,2,3]triazole, obtained in Example 45. After stirring 30 min at room temperature, 5 drops of methyl iodide was added and the mixture was further stirred for 1 hour at room temperature.

Workup

  1. customobtained in Example 45
  2. stirringthe mixture was further stirred for 1 hour at room temperature

Sources & evidence

ORD record
ord-90217c9637f14ba696263e31c0ffd11f
Source dataset
uspto-grants-2011_03
Patent number
US07902369B2

Reaction notes

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