反应详情

Under nitrogen atmosphere, 22 mg of 60% sodium hydride was added at 0° C. to 3 ml solution of dimethylformamide with 100 mg of 6-bromo-2H-isoquinoline-1-one, and the mixture was stirred for 30 min. 0.04 ml of ethyl iodide was added at 0° C., and the mixture was stirred at room temperature for 3 hours. Cold water was added to the reaction solution, extracted with chloroform. Chloroform layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. After distilling out the solvents under reduced pressure, the residues were separated and purified by thin-layer chromatography (hexane/ethyl acetate=3/1) to obtain 30 mg of the above compound as a white solid.

1. stirringthe mixture was stirred at room temperature for 3 hours
2. extractionextracted with chloroform
3. washChloroform layer was washed with saturated saline solution
4. dry with materialdried with anhydrous sodium sulfate
5. distillationAfter distilling out the solvents under reduced pressure
6. customthe residues were separated
7. custompurified by thin-layer chromatography (hexane/ethyl acetate=3/1)