Hydrochloric Acid → HCID 178439188, compound

HRID 602249Notes

Reaction equation

HRID 602249 reaction equation
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[C:7]([CH:27]=[O:28])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[OH:29]O.Cl>[OH-].[Na+]>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:23][N:24]=[N:25][N:26]=3)=[CH:14][CH:15]=2)[C:7]([C:27]([OH:29])=[O:28])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 178439171HCID 178439171, compound

Product 1

HCID 178439188HCID 178439188, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
0 °C

Procedure

100 mg of compound 2 (0.269 mmol) are dissolved in 50 mL of 0.1 N NaOH and 158 mL (1.6 mmol) of 35% H2O2 are added. The mixture is left to stand at ambient temperature for 18 h. The mixture is cooled to 0° C. and adjusted to pH 2 with 2N HCl. The solid is filtered out and washed with water. Drying is performed in a vacuum oven at 40° C. Product: 54 mg. Formula: C22H21N5O2 (m.w. 387.43). Yield 52%.

Workup

  1. waitThe mixture is left
  2. filtrationThe solid is filtered out
  3. washwashed with water
  4. customDrying
  5. customis performed in a vacuum oven at 40° C

Sources & evidence

ORD record
ord-0e55acb87ead4a56a057c91c71235fdc
Source dataset
uspto-grants-2011_03
Patent number
US07906501B2

Reaction notes

Loading…