Hydrochloric Acid → HCID 5302967, compound

HRID 602502Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:17])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=1[O:15][CH3:16])[CH3:2].Cl.C(=O)(O)[O-].[Na+]>C(O)C.[Fe]>[CH2:1]([O:3][C:4](=[O:17])[NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=1[O:15][CH3:16])[CH3:2]

Participants

Conditions

Temperature: 65 °C

Procedure

(2-Methoxy-4-nitrophenyl)-carbamic acid ethyl ester (2.20 g) was dissolved in ethanol (220 mL). Aqueous hydrochloric acid (26 mL, 6 M) and iron powder (4.74 g) were added, and the mixture was stirred at 65° C. for 15 minutes. After cooling to room temperature, the mixture was neutralised with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (3×200 mL). The organic phase was washed with water (2×100 mL) and brine (100 mL), dried over magnesium sulfate, filtered, and evaporated in vacuo. The crude product was dissolved in ethanol (100 mL), and the above procedure was repeated using aqueous hydrochloric acid (26 mL, 6M) and iron powder (3.7 g), to yield the title compound as a dark oil (1.80 g, 93%). 1H NMR (DMSO-d6): 1.19 (t, 3H), 3.67 (s, 3H), 4.01 (q, 2H), 4.97 (s, 2H), 6.08 (dd, 1H), 6.23 (d, 1H), 6.97 (br. s, 1H), 7.92 (br. s, 1H).

Workup

temperatureAfter cooling to room temperature
extractionextracted with ethyl acetate (3×200 mL)
washThe organic phase was washed with water (2×100 mL) and brine (100 mL)
dry with materialdried over magnesium sulfate
filtrationfiltered
customevaporated in vacuo
dissolutionThe crude product was dissolved in ethanol (100 mL)

Sources & evidence

ORD record: ord-f3b173c2cd084b53b4829b8cab125b83
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906537B2

Reaction notes

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